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Modulators of liver X receptors
专利权人:
Inc.;Vitae Pharmaceuticals
发明人:
DONG, Chengguo,FAN, Yi,LEFTHERIS, Katerina,LOTESTA, Stephen,SINGH, Suresh B.,TICE, Colin,ZHAO, Wei,ZHENG, Yajun,ZHUANG, Linghang
申请号:
ES13712103
公开号:
ES2607113T3
申请日:
2013.03.14
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound represented by the following structural formula: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: X is N or CRc; R1 is alkyl or -NRaRb; R2 is H; halogen; -CN; -NRC (O) R; -C (O) OR; -C (O) NRaRb; monocyclic heteroaromatic optionally substituted with one or more groups selected from alkyl, -CN, -NRC (O) R, -C (O) OR, -C (O) NRaRb and halogen; monocyclic non-aromatic heterocycle optionally substituted with one or more groups selected from alkyl, halogen, -CN and>; = O; or alkyl optionally substituted by one or more groups selected from halogen, hydroxy, alkoxy, -NRaRb, -NRC (O) R, -NRC (O) O (alkyl), -NRC (O) N (R) 2, -C (O) OR, thiol, alkylthiol, nitro, -CN,>; = O, -OC (O) H, -OC (O) (alkyl), -OC (O) O (alkyl), -OC (O) N (R) 2 and -C (O) NRaRb. R3 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, monocyclic non-aromatic heterocycle, monocyclic heteroaromatic or phenyl, wherein the phenyl group, monocyclic non-aromatic heterocycle and monocyclic heteroaromatic represented by R3 are optionally substituted with one or more selected alkyl groups, halogen, haloalkyl, alkoxy, haloalkoxy, nitro and -CN. R4 and R5 are independently halogen, -CN, -OR, -SR, -N (R) 2, -C (O) R, -C (O) OR, -OC (O) O (alkyl), -C ( O) O (haloalkyl), -OC (O) R, -C (O) N (R) 2, -OC (O) N (R) 2, -NRC (O) R, -NRC (O) O ( alkyl), -S (O) R, -SO2R, -SO2N (R) 2, -NRS (O) R, -NRSO2R -NRC (O) N (R) 2, -NRSO2N (R) 2, haloalkyl, haloalkoxy , cycloalkoxy, cycloalkyl, monocyclic non-aromatic heterocycle, monocyclic heteroaromatic or alkyl, wherein the alkyl, monocyclic non-aromatic heterocycle and monocyclic heteroaromatic group represented by R4 or R5 are optionally substituted with one or more groups selected from -CN, -OR, - SR, -N (R) 2,>; = O, -C (O) R, -C (O) OR, -C (O) O (haloalkyl), -OC (O) R, -OC (O) O (alkyl), -C (O) N (R) 2, -OC (O) N (R) 2, -NRC (O) R, -NRC (O) O (alkyl), -S (O) R, -SO2R, -SO2N (R) 2, -NRS (O) R, -NRSO2R, -NRC (O) N (R) 2 and -NRSO2N (
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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