The invention relates to novel polymorphs of picropodophyllin, methods for preparing said polymorphs and pharmaceutical compositions comprising said polymorphs, as well as the use of said polymorphs in therapy such as cancer therapy.Linvention concerne de nouveaux polymorphes de picropodophylline, des procédés de préparation desdits polymorphes et des compositions pharmaceutiques comportant lesdits polymorphes, ainsi que lutilisation desdits polymorphes en thérapie, par exemple en thérapie anticancéreuse.