Anti-FGFR antibodies which bind to particular isoforms of FGFR1-4, therapeutic compositions comprising the anti-FGFR antibodies, and methods of using such antibodies and compositions in the treatment of FGFR-related disorders (e.g., cancer) are disclosed.本發明揭示結合至FGFR1-4之特定同功異型物的抗FGFR抗體、包含該等抗FGFR抗體的治療組合物,以及使用此類抗體及組合物治療FGFR相關病症(例如癌症)的方法。