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2-PHENYL-4-CYCLOPROPYL-PYRIMIDINE DERIVATIVES
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
CAROFF, EVA,MEYER, EMMANUEL
申请号:
NZ58916909
公开号:
NZ589169A
申请日:
2009.04.09
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
The disclosure relates to 2-phenyl-4-cyclopropyl-pyrimidine derivatives of formula (I), wherein R1 represents phenyl optionally substituted once by halogen, methyl, methoxy, trifluoromethyl or trifluoromethoxy and R2 represents hydrogen, hydroxymethyl or alkoxymethyl. These compounds of formula (I) are suitable for use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.
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