#$%^&*AU2014280913A120150122.pdf#####Abstract The invention provides a compound of Formula I: 0 N 0N N 5 Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.