吉利德康涅狄格有限公司;GENENTECH, INC.;遗传技术研究公司; Inc.;遺傳技術研究公司;Gilead Connecticut;Gilead Connecticut, Inc.
发明人:
CURRIE, Kevin S.,K．S．柯里,WANG, Xiaojing,X．王,YOUNG, Wendy B.,W．B．杨,W．B．楊,K.S.柯里,X.王,W.B.杨,W.B.楊
申请号：
MOJ002420
公开号：
MOJ002420B
申请日:
2016.11.23
申请国别(地区):
MO
年份:
2017
代理人:
摘要：
The present invention provides the pyridone and pyridazinone compound of Formulas I, including its stereoisomer, tautomer and pharmaceutically acceptable salt, inhibits Btk kinases, and the inflammation for example kinase mediated by Btk with what treatment immune conditions with what. The present invention disclose using compound of formula I in vitro, the method for original position and in-vivo diagnostic and such illness or relevant pathological state in treatment mammalian cell.本發明提供式I的吡啶酮和噠嗪酮化合物，包括其立體異構體、互變異構體和藥學可接受的鹽，其用於抑制Btk激酶，並用於治療免疫性病症例如由Btk激酶介導的炎症。本發明公開使用式I化合物在體外、原位和體內診斷和治療哺乳動物細胞中的此類病症或相關的病理狀態的方法。
