Andrew J. Murphy,Dimitris Skokos,Janelle Waite,Erica Ullman,Aynur Hermann,Eric Smith,Lauric Haber,George D. Yancopoulos,Alison Crawford
申请号：
US16719273
公开号：
US20200199233A1
申请日:
2019.12.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD28, and a second antigen-binding molecule that specifically binds human MUC16. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing MUC16, such as ovarian tumors. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an up-regulated or induced targeted immune response is desired and/or therapeutically beneficial.
