A surgical instrument for surgically joining tissue is disclosed. The surgical instrument comprises a handle assembly, an elongated portion extending distally from the handle assembly, an end effector disposed adjacent a distal portion of the elongated portion, and an articulation mechanism disposed in mechanical cooperation with the end effector. The articulation mechanism comprises a lever, a first set of teeth, a second set of teeth, a first plunger for engaging the first set of teeth, and a second plunger for engaging the second set of teeth. A predetermined amount of rotation of the lever in a first direction moves at least a portion of the first plunger away from the first set of teeth. A predetermined amount of rotation of the lever in a second, opposite direction moves at least a portion of the second plunger away from the second set of teeth.