Erasmus University Medical Center Rotterdam;Craig, Roger Kingdon
发明人:
CRAIG, Roger Kingdon,GROSVELD, Franklin Gerardus,JANSSENS, Richard Wilhelm,VAN HAPEREN, Magnus Johannes
申请号：
DK09760275
公开号：
DK2379727T3
申请日:
2009.11.30
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
A non-human mammal containing an endogenous lambda light chain gene locus, an endogenous kappa light chain gene locus and an endogenous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge but said loci have been mutated so that the ability to form functional immunoglobulin tetramers comprising re-arranged heavy and light chains produced from said mutated loci has been substantially reduced or eliminated.
