The present invention provides a process of enhancing the solubility of water insoluble drugs or sparingly water soluble drugs using vitamin E-TPGS (d-alpha tocopheryl polyethylene glycol 1000 succinate) as a solubliser and various adsorbents like aerosol 200, aeroperl 300 and neusilin. The present invention also provides a melt dispersion of water insoluble drugs or sparingly water soluble drugs and an oral dosage from containing the melt dispersion.