#$%^&*AU2019382299A120200716.pdf#####Abstract The present invention discloses an application of a polypeptide in preparing a composition for preventing and treating human papillomavirus infection, belonging to the field of infectious disease treatment. In addition, the present invention provides a polypeptide composition for 5 preventing and treating human papillomavirus infection. The polypeptide composition is prepared by taking an effective dose of the polypeptide as an active ingredient, and adding a pharmaceutically acceptable adjuvant or auxiliary ingredient. The polypeptide of the present invention can be used for the treatment and prevention of human papillomavirus infection, having significant effect, no inhibitory effect on the normal flora of the female genital tract, and showing 10 good safety. 19