BRAVO GONZÀLES, ROBERTO CARLOS,BUSER, THOMAS,GOUTTE, FRÉDÉRIC JEAN-CLAUDE,BASIT, ABDUL WASEH,VARUM, FELIPE JOSÉ OLIVEIRA,FREIRE, ANA CRISTINA
申请号：
PL12166110
公开号：
PL2659881T3
申请日:
2012.04.30
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.
