Systems and methods of medical imaging includes acquiring a plurality of projection images. A first projection image and a second projection image from the plurality of projection images are selected that are adjacent to a received focal point. A first set of object locations in the first projection image and a second set of object locations in the second projection image are identified that contribute to a pixel of the synthetic projection image. A value for the pixel of the synthetic projection image is calculated from the pixels of the first set of object locations and the pixels of the second set of object locations. The synthetic projection image is created with the calculated value.
