The present invention relates to compositions, uses thereof, and methods of vaccinating cattle, particularly cows and heifers, against Leptospira borgpetersenii serovar hardjo (type hardjo-bovis) by using Leptospira interrogans serovar hardjo (type hardjoprajitno).La presente invención se refiere a composiciones, a usos de las mismas y a métodos para vacunar ganado vacuno, particularmente vacas y terneras, contra Leptospira borgpetersenii serovariedad hardjo (tipo hardjo-bovis) usando Leptospira interrogans serovariedad hardjo (tipo hardjoprajitno).