This disclosure offers the manner in order to inspect nervous generation, neurocyte breeding and differentiation. Concretely, this disclosure regards the manner which identifies the medicine the screening are done manner, and nervous generation and the gene which adjusts the breeding of manner, nervous generation and the nervous precursive cell which identify the medicine which can adjust nervous generation and neurocyte breeding nervous breeding or the differentiation which as a candidacy adjustment factor. In addition as for this disclosure, the manner which remedies the patient with the medicine and this medicine which are identified by manner and this manner which identify the medicine which characterizing and you adjust nervous generation, and it regards the constituent which includes the medicine which catches. Therefore, as for this manner, nervous generation, generation of the brain and elucidation of the feature which adjusts function are made possible in the fault of the healthy animal and nervous system. Furthermore, this manner in the various nervous system faults which include acknowledgment fault, it prevents the nervous generation which is impaired, it makes the development of the constituent which you improve or is stabilized, or easy.本開示は、神経発生、神経細胞増殖および分化を調べるための方法を提供する。具体的に、本開示は、神経発生および神経細胞増殖を調節し得る薬剤を同定する方法、神経発生および神経前駆細胞の増殖を調節する遺伝子をスクリーニングする方法、ならびに神経発生および神経増殖または分化の候補調節因子としての薬剤を同定する方法に関する。本開示はまた、神経発生を特徴づけおよび調節する薬剤を同定する方法、かかる方法により同定された薬剤、かかる薬剤で患者を治療する方法、ならびにかかる薬剤を含む組成物に関する。したがって、本方法は、健常な動物および神経系の障害において神経発生、脳の発生および機能を調節する機構の解明を可能にする。さらに、本方法は、認知障害を含む種々の神経系障害における損なわれた神経発生を予防、改善または安定化する組成物の開発を容易にする。
