Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by THR beta.本文提供化合物,較佳甲狀腺素受體β (THR β)促效劑化合物、其組合物,及其製備方法,及促效THR β之方法,及用於治療THR β介導之病症之方法。