SCHIBLI, ROGER,MOSER, RUDOLF,MÜLLER, CRISTINA MAGDALENA,AMETAMEY, SIMON MENSAH,ROSS, TOBIAS LUDWIG,GROEHN, VIOLA
申请号：
ES09783938
公开号：
ES2548140T3
申请日:
2009.10.12
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula II ** Formula ** wherein X1 to X5 are independently from each other C or N, R1 and R2 are independently from each other H, Hal, -OR ', -NR "R"', C1-C12 alkyl, C1-C12 alkoxy, C1-C12 alkanoyl, C2-C12 alkenyl, C2-C12 alkynyl, (C1-C12 alkoxy) carbonyl and (C1-C12-amino) carbonyl alkyl, wherein R 'is H or C1-C6 alkyl, and wherein R "and R" 'are independently selected from H, formyl, straight or branched chain C1-C12 alkyl, which is unsubstituted or substituted with at least one CN, Hal or NO2, and in where one or more embedded CH2 groups, not adjacent, may be independently replaced by -O-, -CO-, -CO-O-, -CO-NR'-, -CH>； = CH-, - C≡C-, wherein R 'is H or C1-C6 alkyl, R3, R4 are, independently of each other, H, formyl, trifluoroacetyl, iminomethyl, nitrous, C1-C12 straight or branched chain alkyl, which is not substituted or substituted with at minus one CN, Hal or NO2, and where one or more non-adjacent CH2 groups, embeb gone, they can be independently replaced by -O-, -CO-, -CO-O-, -CO-NR'-, -CH>； = CH-, -C≡C-, where R 'is H or C1 alkyl -C6, or R3 and R4 together form a C1 or C2 bridge between X3 and X5, R5 is H, C1-C12 alkyl, C1-C12 alkoxy, C1-C12 alkanoyl, C2-C12 alkenyl, C2-C12 alkynyl, (alkoxy C1-C12) carbonyl and (C1-C12-amino) carbonyl alkyl, m is 0 or 1, p is 0, 1 or 2, which has a value of 1 to 7, Xa, Xb are independently of each other C, N, O, S, Ra, Rb are independently from each other H or C1-C12 straight or branched chain alkyl, C3-C6 cycloalkyl, C5-C14 aryl or C5-C14 heteroaryl which, independently of one another, is unsubstituted or substituted with at least one CN, Hal or NO2 and in which one or more of the non-adjacent CH2 groups, embedded, may be independently replaced by -O-, -CO-, -CO-O-, - CO-NR'-, -SO2-, -CH>； = CH-, -C≡C-, wherein R 'is H or C1-C6 alkyl； Z1, Z2 are, independently of each other, H or 18F, with the proviso that one of Z1 and Z2 is 18F.Un compuesto de fórmula II**Fórmula** en donde X1 a X5 son independienteme
