The present invention relates to the field of drugs and discloses novel nitrogenous heterocyclic derivatives, its manufacturing method and drug uses, especially used for treatment and prevention and treatment of tissue fibrosis. The present invention also discloses a drug composition including the invention and acceptable in pharmacy, and uses by using the composition for treatment of diseases of tissue fibrosis of human or animals, especially uses for the treatment of humen or animals in renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, retroperitoneal fibrosis, myocardial fibrosis, skin fibrosis, post-surgical adhesions, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, muscle tumors, neurofibromatosis, pulmonary fibrosis, diabetes, kidney disease, Alzheimers disease, or vascular fibrosis.本發明涉及藥物領域,公開了新的氮雜環衍生物,其製備方法以及作為藥物尤其是作為治療和預防治療組織纖維化疾病的藥物的用途。本發明也公開了藥學上可接受之包含本發明化合物的藥物組合物和使用其組合物治療人體或動物組織纖維化疾病的用途,特別是在治療人體或動物腎間質纖維化、腎小球硬化、肝纖維化、肺纖維化、腹膜纖維化、心肌纖維化、皮膚纖維化、手術後黏連、良性前列腺肥大症、骨骼肌纖維化、硬皮病、多發性硬化症,胰腺纖維化,肝硬化,肌肉瘤,神經纖維瘤,肺間質纖維化,糖尿病腎病,阿爾茨海默病或血管纖維化疾病中的用途。
