This invention is directed to fusion proteins comprised of one or more protein sequences of the glioma pathogenesis-related (GLIPR) family of proteins coupled to non-GLIPR protein sequences, to nucleic acid constructs and vectors comprising encoding fusion proteins and peptides, and to methods related to fusion proteins and peptides in the treatment of diseases. In particular, the invention is directed to GLIPR sequences coupled to sequences of antibodies and/or other immune system proteins and peptides, and methods related to fusion proteins in the treatment of prostate cancer.