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N-(2-HIDROXIETIL)-N-METIL-4-(QUINOLIN-8-IL(1-(TIAZOL-4-ILMETIL)PIPERIDIN-4-ILIDEN)METIL)BENZAMIDA
专利权人:
ASTRAZENECA AB
发明人:
BUI, KHANH,DANTZMAN, CATHY,ERNST, GLEN,HOESCH, VALERIE,HUDZIK, THOMAS,KING, MEGAN MURPHY,LIU, JIE,YAN, JINGBO
申请号:
PE0010602012
公开号:
PE06342014A1
申请日:
2012.07.24
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
Refers to a compound such as n - (2 - hydroxyethyl) - N - methyl - 4 - (quinolin-1 (IL - 8 - 1 - (4 - Methyl thiazole - ylidene) piperidin-4-yl) methyl) benzamide.It also relates to a Pharmaceutical Composition and a preparation Method, which comprises: a) reacting with ethanol, 2 - (methylamino) [4 - bromo - (4 - Carboxy phenyl) methylene] - piperidine protected for 4 - bromo - (4 - [(2 - hydroxy ethyl) - methyl phenyl Carbamoyl]} - methylene) - piperidine protected (b) reacting (4 - bromo - (4 - [(2 - hydroxy ethyl) - methyl] phenyl Carbamoyl) - methylene) - piperidine prot8 - quinolinborico Aegis with acid to form N - (2-hydroxy ethyl) - N - methyl - 4 - (piperidin-4-yl quinolin-1 IL - 8 - - ylidene methyl) - benzamide protected (c) check out the compound obtained in the step (b) and (d) to react with N - (2 - hydroxy Ethyl) - N - methyl - 4 - (piperidin-4-yl quinolin-1 IL - 8 - - ylidene methyl) - benzamide with Tiaz Ol - 4 - carbaldehido to form N - (2 - hydroxyethyl) - N - methyl - 4 - (quinolin-1 (IL - 8 - 1 - (4 - Methyl thiazole piperidi)N - 4 - ylidene) methyl) benzamideSE REFIERE A UN COMPUESTO TAL COMO N-(2-HIDROXIETIL)-N-METIL-4-(QUINOLIN-8-IL(1-(TIAZOL-4-ILMETIL)PIPERIDIN-4-ILIDEN)METIL)BENZAMIDA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: A) HACER REACCIONAR 2-(METILAMINO)ETANOL CON 4-[BROMO-(4-CARBOXI-FENIL)-METILEN]-PIPERIDINA PROTEGIDA PARA OBTENER 4-(BROMO-{4-[(2-HIDROXI-ETIL)-METIL-CARBAMOIL]-FENIL}-METILEN)-PIPERIDINA PROTEGIDA B) HACER REACCIONAR 4-(BROMO-{4-[(2-HIDROXI-ETIL)-METIL-CARBAMOIL]-FENIL}-METILEN)-PIPERIDINA PROTEGIDA CON ACIDO 8-QUINOLINBORICO PARA FORMAR N-(2-HIDROXI-ETIL)-N-METIL-4-(PIPERIDIN-4-ILIDEN-QUINOLIN-8-IL-METIL)-BENZAMIDA PROTEGIDA C) DESPROTEGER EL COMPUESTO OBTENIDO EN EL PASO (B) Y D) HACER REACCIONAR N-(2-HIDROXI-ETIL)-N-METIL-4-(PIPERIDIN-4-ILIDEN-QUINOLIN-8-IL-METIL)-BENZAMIDA CON TIAZOL-4-CARBALDEHIDO PARA FORMAR N-(2-HIDROXIETIL)-N-METIL-4-(QUINOLIN-8-IL(
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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