A computer-implemented method for active control of ultrasound image acquisition includes accessing image data representing a series of ultrasound images acquired over a period of time from an ultrasound probe and identifying an object of interest in at least one of the images. The method further includes detecting changes in a position of the ultrasound probe and/or an orientation of the ultrasound probe over the period of time with respect to the object of interest, or changes in a position of the object of interest and/or an orientation of the object of interest over the period of time with respect to the ultrasound probe. The method further includes adjusting at least one ultrasound image acquisition parameter based on the detected changes in the position and/or the orientation of the ultrasound probe and/or based on the detected changes in the position and/or the orientation of the object of interest.