The invention describes a retaining and positioning device of a surgical instrument and/or of an endoscope for minimally invasive surgery, more particularly for use within a surgical robot system, including a first axis of rotation, around which a retaining element can be rotated. The first axis of rotation always intersects with a longitudinal axis of at least one surgical instrument and/or of an endoscope in a pivotal point by means of a thrust drive being attached to the retaining element, to which thrust drive an instrument drive unit can be rotatably arranged around the pivotal point. The instrument drive unit has a telescopic arrangement via which the surgical instrument can be moved in a translational manner along the longitudinal axis thereof by means of a guide arrangement in the body in such a manner that the longitudinal axis of the surgical instrument is variably adjustable relative to the telescopic arrangement.