GOVINDAN SERENGULAM V,MCBRIDE WILLIAM J,SATHYANARAYAN NALINI,MAZZA-FERREIRA CHRISTINE,GOLDENBERG DAVID M
申请号：
IN4079/DELNP/2015
公开号：
IN2015DN04079A
申请日:
2015.05.13
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Disclosed are methods compositions and uses of conjugates of prodrug forms of 2 pyrrolinodoxorubicin (P2PDox) with antibodies or antigen binding fragments thereof (ADCs) with targetable construct peptides or with other targeting molecules that are capable of delivering the P2PDox to a targeted cell tissue or pathogen. Once delivered to the target cell the ADC or peptide conjugate is internalized a highly toxic 2 pyrrolinodoxorubicin (2 PDox) is released intracellularly. The P2PDox peptide or ADC conjugates are of use to treat a wide variety of diseases such as cancer autoimmune disease or infectious disease.
