Los Alamos National Security, LLC;Duke University;Dana-Farber Cancer Institute, Inc.
发明人:
Bette T. M. Korber,S. Gnanakaran,Simon Perkins,Joseph Sodroski,Barton Haynes
申请号：
US15025806
公开号：
US09855329B2
申请日:
2014.09.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.
