Constrained fluid delivery devices are described that deliver fluid to an anatomical region of a mammal in a controlled release manner where the device comprises an elongate body defining a lumen throughout a portion thereof, a distal end interiorly positionable adjacent the anatomical region of the mammal and a proximal end in communication with an exterior of the mammal. The device also includes a delivery member and one or more withdrawal members. Also provided herein are methods and kits incorporating the fluid delivery device.