The present disclosure provides a combination therapy to treat neurodegenerative diseases. In one embodiment, Alzheimer's disease is treated with an orally administered mitochondria stimulant, neuro protective antioxidant that crosses the blood brain barrier and is supplemented with a drug that promotes hippocampal neurogenesis. The combination therapy of a mitochondria stimulant, a brain available antioxidant and a neurogenesis agonist, may be employed to prevent, inhibit or treat neurodegenerative diseases that have a root cause of inflammation, oxidative stress, followed by free radical biologic macromolecule destruction, and eventually cell death, such as Parkinson's, age related Dementia, Multiple Sclerosis (MS) and Amyotrophic Lateral Sclerosis (ALS).
