N- [3- (5- (5-amino-3,3a, 7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl) -phenyl] as a BACE1 and / or BACE2 inhibitor -Amides

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专利权人:

エフ．ホフマン－ラ;アーゲー;ロシュ;エフ.ホフマン-ラ ロシュ アーゲー

发明人:

ヒルペルト，ハンス,フム，ローラント,ヒルペルト,ハンス,フム,ローラント

申请号：

JP2013552917

公开号：

JP5914525B2

申请日:

2012.02.06

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to N-[3-(5-Amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

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