Methods and devices for identifying a treatment site are disclosed. The methods may include engaging a plurality electrodes with plurality of locations on or adjacent an interior wall of a patient. The methods may also include generating a pacing stimulus through a first pair of the plurality of electrodes and measuring a resulting electrical activity. The methods may also include identifying at least one site for treatment based on the resulting electrical activity. The devices may include elements configured to perform these methods. The device comprises a plurality of electrodes； a memory device configured to store an instruction for evaluating electrical activity； and a processor configured to: access the instruction from the memory； direct, with the instruction, an electrical energy source to generate a pacing stimulus through a first pair of the plurality of electrodes； measure, with the instruction, a resulting electrical activity at one or more of the plurality of electrodes； and identify, with the instruction, at least one treatment site based the resulting electrical activity. The processor is further configured to initiate, with the instruction, a therapy to the least one treatment site, such as a radio frequency energy, an ultrasound energy, a laser energy, a cryoablation, a microwave ablation, a Botox injection, a neurolytic agent, an optical energy, an irreversible electroporation, and a hydrogel injection.
