The PD-L1 of the antibody glycosylation specifically bound with it arrives the offer that PD-1 PD-L1 promote degradation PD-L1 relative to the PD-L1 being not glycosylated, the combination of block and internalization. The cell that antibody also contributes to internalization PD-L1 to the combination of two blockings PD-L1 to PD-1 that is glycosylated and showing dual function of identification defined epitope PD-L1 albumen provides. In some respects, PD-L1 includes that the amino of the amino acid residue of glycosylated polypeptide and carboxy terminal positions PD-L1 extracellular domains are also provided. Using the method for antibody, it is used for treating cancer, especially PD-L1 positive cancers to be also provided.
