As for this invention, obesity, diabetes and the metabolism fault in the constituent, and the patient who include the complex ring derivative and two cyclic complex ring derivatives of two cyclic types, it regards the manner which uses these two cyclic complex ring derivatives in order the disease of heart vascular type or the disease which it is related to the activity of GPCR it remedies or to prevent, or.本発明は、二環式の複素環誘導体、二環式複素環誘導体を含む組成物、及び患者における肥満、糖尿病、代謝障害、心血管系の疾患又はGPCRの活性に関連する疾患を治療又は予防するためにこの二環式複素環誘導体を用いる方法に関する。