Ingemar Jonsson;Hans Henrik Lidgard;Gustaf Plym Forshell
发明人:
Ingemar Jonsson,Hans Henrik Lidgard,Gustaf Plym Forshell
申请号：
US10543856
公开号：
US08846075B2
申请日:
2004.01.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention refers to a composition material that is intended for rapid transmucosal delivery in the mouth of a biologically active substance when in contact with saliva. The composition material comprises at least one ionic carbohydrate, having at least one biologically active substance ionically bound thereto, and at least one wetable non-soluble polymeric carbohydrate. The invention also refers to a method of preparing the composition material, which comprises the steps of: (a) providing a mixture of the at least one biologically active substance and at least one ionic carbohydrate in a solvent having a permissive pH for ionic bonding of the at least one biologically active substance to the at least one ionic carbohydrate； (b) mixing the mixture in the solvent for a period that is sufficient for allowing the ionic bonding to take place； and (c) recovering the mixture from the solvent.
