A hand rehabilitation device (100) comprising: at least one first support (124) configured to support the thumb of a hand, wherein said at least one first support (124) is designed to perform a flexion/extension movement for rehabilitating said thumb, said flexion/extension movement being actioned by a first transmission mechanism to which the at least one first support (124) is connected； at least one second support (120, 121, 120B) configured to support the index finger of said hand, wherein said at least one second support (120, 121, 120B) is designed to perform a flexion/extension movement for rehabilitating said index finger, said flexion/extension movement being actioned by a second transmission mechanism to which the at least one second support (120, 121, 120B) is connected； at least one third support (122, 123, 122B) configured to support the three remaining fingers-middle ring, and little fingers- of said hand, wherein said at least one third support (122, 123, 122B) is designed to perform a flexion/extension movement for rehabilitating said three remaining fingers, said flexion/extension movement being actioned by a third transmission mechanism to which the at least one third support (122, 123, 122B) is connected； wherein said first, second and third transmission mechanisms are actuated by at least one motor； wherein the three flexion/extension movements of said at least one first support (124), said at least one second support (120, 121, ) and said at least one third support (122, 123, ) are independent from each other.
