Small molecule sensitization of BAX activation for induction of cell death

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专利权人:

Inc.;Dana-Farber Cancer Institute

发明人:

Walensky, Loren D.,Pritz, Jonathan,Wachter, Franziska

申请号：

AU2018236233

公开号：

AU2018236233A1

申请日:

2018.03.14

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

Provided herein are compositions comprising a compound of Formulas I, II, or III, and compositions a compound comprising a moiety of Formula IV, which are useful for sensitizing and/or activating pro-apoptotic activity of BAX. Methods of treating diseases associated with BAX (e.g., cancer) and methods of identifying compounds which sensitize and/or activate the pro-apoptotic activity of a BAX polypeptide are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/