Petrus ROTTIER,Stefanus VAN BEURDEN,Monique VERHEIJE,Egbert MUNDT
申请号：
US15622672
公开号：
US20170360921A1
申请日:
2017.06.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Embodiments of the present invention relate to an infectious bronchitis virus (IBV) and an immunogenic composition comprising an IBV, respectively, wherein the ORF 3a and/or the ORF 3b and/or the ORF 5a and/or the ORF 5b is inactivated. Furthermore, aspects of the present invention relate to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, embodiments of the present invention relate to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the embodiments of the present invention.
