MÉTHODE, TROUSSE, PLASMIDE ET COMPOSITION POUR INDUIRE UNE RÉPONSE IMMUNITAIRE CONTRE LE VIRUS DE LA DENGUE, AU MOYEN DE VACCINS À ADN ET DE VIRUS CHIMÉRIQUES
FUNDACAO OSWALDO CRUZ (FIOCRUZ) - SUPERINTENDENCIA DE PLANEJAMENTO
发明人:
ALVES, ADA MARIA DE BARCELOS,AZEVEDO, ADRIANA DE SOUZA,GALLER, RICARDO,FREIRE, MARCOS DA SILVA
申请号：
EP10819756
公开号：
EP2484376A4
申请日:
2010.08.01
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
This invention refers to a method for inducing an immune response against the dengue virus based on DNA and a chimeric virus 17D vaccines in combined or co-administered immunizations. Also included in the scope of the present invention are DNA vaccines against the four dengue virus serotypes from the construction of different recombinant plasmids containing the gene which codifies protein E, or only the sequence corresponding to domain III of this protein, from each dengue virus serotype (DENV1-4). The invention further provides a vaccine composition consisting of (a) DNA vaccines against the four dengue virus serotypes, (b) chimeric viruses comprising the modified yellow fever vaccine virus 17D； and (c) a pharmaceutically acceptable vehicle, is included in the protection scope.
