A system and method for cardiac resynchronization therapy (&ldquoCRT&rdquo) in which a model of baseline cardiac electrical activity, such as a model of global baseline cardiac electrical activity derived from various surface electrocardiograph (&ldquoECG&rdquo) signals, is utilized to automatically adjust pacing control parameters of a cardiac implantable electrical device (&ldquoCIED&rdquo) are provided. The baseline model is compared to CRT response patterns using modified pacing control parameters in an iterative fashion, based on a patient-specific response pattern phenotype determination, until ventricular electrical asynchrony is minimized. The pacing control parameters resulting in the minimum ventricular electrical asynchrony are used to generate final control parameters for CRT.
