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Benzimidazole derivatives useful as TRPM8 channel modulators
专利权人:
Janssen Pharmaceutica NV
发明人:
Macielag, Mark J.,Xia, Mingde,Xu, Xiaoqing
申请号:
AU2010258713
公开号:
AU2010258713A1
申请日:
2010.06.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows wherein R, R, R, R, R and a are defined herein. The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the TRPM8 (transient receptor potential melastatin subfamily type 8) channel. The present invention also relates to processes for the preparation of benzimidazole derivatives and to their use in treating various diseases, syndromes, and disorders, including, those that cause inflammatory pain, neuropathic pain, cardiovascular diseases aggravated by cold, pulmonary diseases aggravated by cold, and combinations thereof.
来源网站:
中国工程科技知识中心
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