THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY
发明人:
MUNIR, SHIRIN,慕尼尔 锡霖,慕尼爾 錫霖,BROCK, LINDA G.,博克 琳达 G,博克 琳達 G,BUCHHOLZ, URSULA J.,布雀候兹 乌苏拉 J,布雀候茲 烏蘇拉 J,COLLINS, PETER L.,柯林斯 比得 L
申请号:
TW108114132
公开号:
TW202012629A
申请日:
2019.04.23
申请国别(地区):
TW
年份:
2020
代理人:
摘要:
Disclosed are live, chimeric non-humanMononegaviralesvectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.本發明揭示活的非人類單股反鏈病毒目(Mononegavirales)嵌合載體,其可以使細胞表現來自至少一種人類病原體之至少一種蛋白質。另外,本發明揭示根據本發明實施例之包含該等載體之組合物、用於在宿主中引發免疫反應之方法及套組以及製備該等載體之方法。