N-terminal VDAC variants and uses thereof

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专利权人:

Varda Shoshan-Barmatz;Doron Calo

发明人:

Varda Shoshan-Barmatz,Doron Calo

申请号：

US12296239

公开号：

US08440788B2

申请日:

2007.04.10

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates generally to variants and peptides of the mitochondrial protein, voltage-dependent anion channel (VDAC) and to polynucleotides encoding same. In particular, the present invention is directed to N-terminal truncated and mutated VDAC and specific amino acid and polynucleotide sequences thereof useful in inhibiting apoptosis, and to pharmaceutical compositions comprising same useful in the treatment of diseases associated with excess apoptosis.

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