雙特異性抗-BCMA x抗-CD3抗體及其用途农业专利-农业学术服务平台

发明人:: SMITH, ERIC,史密斯　艾瑞克,OLSON, KARA,欧森　卡拉,歐森　卡拉,DELFINO, FRANK,达菲诺　法兰克,達菲諾　法蘭克,DILILLO, DAVID,迪利罗　大卫,迪利羅　大衛,KIRSHNER, JESSICA,基什内尔　洁西卡,基什內爾　潔西卡,SINESHCHEKOVA, OLGA,锡尼什契科瓦　奥尔加,錫尼什契科瓦　奧爾加,ZHANG QIAN

摘要：: B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides novel bispecific antibodies (bsAbs) that bind to both BCMA and CD3 and activate T cells via the CD3 complex in the presence of BCMA-expressing tumor cells. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of various cancers, including multiple myeloma.B細胞成熟抗原(BCMA)在惡性漿細胞上表現。本發明提供結合BCMA及CD3兩者且在表現BCMA之腫瘤細胞存在下經由CD3複合物活化T細胞之新穎雙特異性抗體(bsAb)。在某些實施例中，本發明之雙特異性抗原結合分子能夠抑制表現BCMA之腫瘤生長。本發明之雙特異性抗原結合分子適用於治療其中上調或誘導之靶向BCMA的免疫反應為所期望的及/或在治療上有益之疾病及病症。舉例而言，本發明之雙特異性抗體適用於治療各種癌症，包含多發性骨髓瘤。