CAMPBELL, JAMIE,SANDY, NIKOLE,TUNA, MIHRIBAN,WOLLERTON VAN HORCK, FRANCISCA,EVERETT, KATY LOUISE,GASPAR, MIGUEL,KRAMAN, MATTHEW,KMIECIK, KATARZYNA,FAROUDI, MUSTAPHA,FOSH, NATALIE,HEBEIS, BARBARA
申请号：
CA3027612
公开号：
CA3027612A1
申请日:
2017.06.20
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure relates to antibody molecules which bind to programmed death-ligand 1 (PD-L1) and lymphocyte-activation gene 3 (LAG-3). The antibody molecules preferably comprise a CDR-based antigen binding site for PD-L1, and a LAG-3 antigen binding site which may be located in two or more structural loops of a CH3 domain of the antibody molecule. The antibody molecules of the disclosure find application, for example, in cancer therapy.
