PROBLEM TO BE SOLVED: To provide an external preparation for wrinkles that is effective for reducing wrinkles or fine wrinkles.SOLUTION: The present invention relates to an external preparation for wrinkles where an N-acyl derivative of Pro-Hyp or its salt which improves the collagen production capacity of fibroblasts is applied to skin, an ion introduction device is combined, to improve skin penetrability, so that it has excellent wrinkle improving effect.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】シワや小ジワの低減に有効なシワ用皮膚外用剤を提供する。【解決手段】線維芽細胞のコラーゲン産生能を高めるPro-HypのＮ－アシル誘導体またはその塩を皮膚に塗布し、イオン導入機器を併用することで皮膚への浸透性を高め、シワ改善効果に優れたシワ用皮膚外用剤に関する。【選択図】なし
