The United States of America as represented by the Department of Veterans Affairs
发明人:
Richard H. Weisbart,Robert N. Nishimura
申请号：
US15042106
公开号：
US10683363B2
申请日:
2016.02.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.
