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NON-DIFFUSIVE BOTULINUM TOXIN CAUSING LOCAL MUSCLE PARALYSIS, AND PURIFICATION METHOD THEREOF
专利权人:
MEDEXGEN INCORPORATED
发明人:
Yong Hoon CHUNG,Hyun Sub LEE
申请号:
US15422129
公开号:
US20170143849A1
申请日:
2017.02.01
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention relates to a method for purifying a non-spreading botulinum toxin that causes local muscle paralysis and a non-spreading botulinum toxin obtained thereby. The method comprises the steps of: subjecting a purified botulinum toxin type A product to ion-exchange chromatography using a controlled pH of buffer, concentration of sodium chloride (NaCl), thereby separating the botulinum toxin type A product into subfractions; and collecting a subfraction having an A260/A280 value in a specific range from the separated subfractions.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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