#$%^&*AU2014201676A120140403.pdf#####MULTIVALENT MENINGOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE Abstract The present invention describes a combined vaccine that offers broad protection 5 against meningococcal disease caused by the pathogenic bacterial Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming to polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of A. meningitidis strains in children as well as adults.
