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METHOD FOR REPROGRAMMING OF HUMAN DENTAL PULP CELL USING OCT4 AND SOX2 AND USE THEREOF
专利权人:
发明人:
Yee Sook Cho,Chae Wha Yoo,Hee Jun Na
申请号:
US14340991
公开号:
US20150299665A1
申请日:
2014.07.25
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to a method for producing endothelial progenitor cells, comprising a method for producing induced pluripotent stem cells by using only Oct4 and Sox2 as a reprogramming factor of human dental pulp cells, and differentiating endothelial progenitor cells from the induced pluripotent stem cells produced by the method for producing induced pluripotent stem cells. Moreover, the present invention relates to a method for producing endothelial cells, comprising differentiating endothelial cells from endothelial progenitor cells produced by the method for producing the endothelial progenitor cells. Additionally, the present invention relates to a method for producing smooth muscle cells, comprising differentiating smooth muscle cells from endothelial progenitor cells produced by the method for producing the endothelial progenitor cells.Also, the present invention make a significant contribution to treatment of ischemia disease and heart disease because a patients dental pulp cell-derived differentiated cells can be used for cell treatment as a result of the cell treatment effect of the endothelial progenitor cells in a mouse model induced to have hind limb ischemia or myocardial infarction.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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