β-glucans are incorporated with liposomes in therapeutic compositions for topical application to prevent or alleviate the conditions and symptoms of cosmetic and dermatologic disorders. In particular, β-glucan is combined with liposomes to increase the penetration of the β-glucan into the skin, to provide hydration of the skin during treatment. The deeper penetration of the β-glucan increases macrophage activity to remove scar tissue, dead skin cells and other foreign debris as well as stimulating collagen growth to improve skin health.