Heterocyclic carboxamide compounds substituted sulfonamide modulators or, as for the Orphan nuclear receptor rorgama； Pharmaceutical composition that is useful for the treatment of rheumatoid arthritis, lupus, psoriasis, multiple sclerosis, Type 1 diabetes, Ulcerative colitis, chronic obstructive pulmonary disease, among others.
GEGE, CHRISTIAN,KINZEL, OLAF,KLEYMANN, GERALD,HOFFMANN, THOMAS,STEENECK, CHRISTOPH
申请号：
CL2014003277
公开号：
CL2014003277A1
申请日:
2014.11.28
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1&prime；), (100), (100&prime；), (200) and (200&prime；) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE TIAZOL SUSTITUIDO POR CARBOXAMIDA, MODULADORES DEL RECEPTOR NUCLEAR HUÉRFANO RORGAMMA, A UNA COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE Y A SU USO EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, LUPUS ERITEMATOSO, PSORIASIS, ENFERMEDAD DE CROHN, ENFERMEDAD PULMONAR OBSTRUCTIVA, ENTRE OTRAS
