Pharmaceutical compositions and single unit dosage forms of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione,or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate,hydrate, or clathrate, are provided herein. Alsoprovided are methods of treating, managing, or preventing various disorders,such as cancer or an inflammatory disease.