The present invention relates to natural anti-bacterial toothpaste composition containing improvement in tooth pain, antibacterial mouth and nerve stability and particularly, it enables to contribute to improvement in tooth pain, antibacterial mouth and nerve stability, which represent effects of Na2SiO3-10H20 and oriental medicine, due to more than 63˜75% of SiO3, and Na2SiO3-10H20 and oriental medicine containing natural minerals like calcium, iron, magnesium, etc.